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Introduction:
Chloramphenicol is derived from Streptomyces venezuelae and has a broad spectrum of activity against gram-positive and gram-negative bacteria. It is often used for selection in molecular biology with the cyt B gene.
See product info sheet for more information.
C252 Chloramphenicol
| Synonym: | [R-(R*,R*)]-2,2-Dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4- nitrophenyl)ethyl]acetamide, Chloromycetin, CAP |
| CAS: | 56-75-7 |
| Formula: | C11H12Cl2N2O5 |
| Molecular Wt: | 323.13 |
Properties
| Form: | Powder |
| Appearance: | Off-white to Yellow |
| Application: | Antibiotic |
| Solubility: | Soluble in water at up to 2.5 mg/mL per the Merck Index. More highly soluble in ethanol. Consult the certificates of analysis for lot-specific solubility information |
| Storage Temp: | Room Temperature |
| Storage Temp of Stock Solution: | Store at 2-6°C for 30 days. Protect from light. |
| Typical Working Concentration: | Varies by application, should be determined by end user |
| Other Notes: | Derived from Streptomyces venezuelae. Plant Tissue Culture Tested |
Application Notes
Chloramphenicol is derived from Streptomyces Venezuelae and has a broad spectrum of activity. It is often used for bacterial selection in molecular biology. Chloramphenicol is effective against grampositive and gram-negative bacteria. It functions by binding to the 50S ribosomal unit to prevent aminoacyl tRNA from binding to the ribosome which prevents elongation of protein chain.
References
Merck 13, 2087 Sweetman SC (ed), Martindale: The Complete Drug Reference 35. China: Pharmaceutical Press, 2007