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Introduction:
A broad spectrum antibiotic that has a high affinity for cell wall-synthesizing enzymes. It is a beta-lactam and belongs to the subgroup of carbapenem. The spectrum of action includes many gram-positive and gram-negative bacteria (including Pseudomonas) and anaerobic bacteria.
M5600 Meropenem
Synonym: MS Modified Vitamin Solution
Properties
| Form: | Powder |
| Appearance: | White to Light Yellow |
| Application: | Antibiotic |
| Solubility: | Water |
| Storage Temp: | 2-6°C |
| Typical Working Concentration: | Varies by application. Concentration should be determined by end user |
| Other Notes: | Plant Tissue Culture Tested |
Application Notes
A broad spectrum antibiotic that has a high affinity for cell wall-synthesizing enzymes. Meropenem is very effective because it resists inactivation by the majority of microbial LACTB (β-lactamases). It is a beta-lactam and belongs to the subgroup of carbapenem. Meropenem is bactericidal except against Listeria monocytogenes where it is bacteriostatic. It inhibits bacterial wall synthesis like other beta-lactam antibiotics. In contrast to other beta-lactams, it is highly resistant to degradation by beta-lactamases or cephalosporinases.
The spectrum of action includes many gram-positive and gram-negative bacteria (including Pseudomonas) and anaerobic bacteria.
Konagaya et al. note the successful elimination of Agrobacterium from Cryptomeria japonica (Japanese cedar) cultures using a concentration of 10 mg/L of Meropenem without observing phytotoxic effects.
References
Kayser, F H., et al., (1989) Activity of meropenem, against gram-positive bacteria. The Journal of antimicrobial chemotherapy. 24: 101-12. Konagaya, K. I., Kurita, M., & Taniguchi, T. (2013). High-efficiency Agrobacterium-mediated transformation of Cryptomeria japonica D. Don by co-cultivation on filter paper wicks followed by meropenem treatment to eliminate Agrobacterium. Plant Biotechnology, 30(5), 523-528.